Thrombus-specific manganese-based “nanobialys” for MR molecular imaging of ruptured plaque

نویسندگان

  • Dipanjan Pan
  • Shelton D Caruthers
  • Angana SenPan
  • Anne H Schmieder
  • Todd A Williams
  • Michael J Scott
  • Patrick J Gaffney
  • Samuel A Wickline
  • Gregory Lanza
چکیده

Mathematical modeling studies have suggested that nonspherical, disc-shaped nanoparticles may have optimal intravascular flow and homing characteristics. In this study, we report the development of a fibrin-specific high-relaxivity bialy-shaped polymeric nanoparticle using porphyrin-chelated manganese. We anticipate that this agent would be highly effective for molecular imaging of microthrombi in ruptured atherosclerotic plaques.

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عنوان ژورنال:

دوره 14  شماره 

صفحات  -

تاریخ انتشار 2012